雷贝拉唑治疗消化性溃疡伴幽门螺杆菌阳性117例疗效评价

Rabeprazole for Treating Peptic Ulcer with Helicobacter Pylori Positive in 117 Cases

目的探讨雷贝拉唑治疗消化性溃疡伴幽门螺杆菌(HP)阳性的效果。方法选择2013年3月至2015年3月医院收治的234例HP为阳性的消化性溃疡患者,随机均分为治疗组和对照组,各117例。治疗组采用雷贝拉唑治疗,对照组采用奥美拉唑治疗。结果治疗1 d后,治疗组上腹疼痛的缓解率为72.65%,明显高于对照组的33.33%,1周后,治疗组的上腹疼痛缓解率达100.00%;治疗1 d后,两组患者临床症状如上腹胀痛、嗳气、反酸、恶心等均显著改善,且治疗组改善幅度更明显(P<0.05);治疗组患者的溃疡愈合时间及HP根除时间显著少于对照组,溃疡愈合率为93.16%,高于对照组的73.50%,HP根除率为95.73%,高于对照组的78.63%(P<0.05);治疗组的总有效率为97.44%,显著高于对照组的88.03%(P<0.05);治疗后1年的随访调查中,治疗组的溃疡复发率和HP再感染率明显低于对照组(P<0.05);治疗后2年的随访调查中,两组的溃疡复发率和HP再感染率均有增加,但治疗组的复合率和感染率明显低于对照组(P<0.05)。结论雷贝拉唑较奥美拉唑用于改善阳性HP消化性溃疡效果更显著,能缓解患者的临床症状,提高溃疡愈合率,降低HP感染率,值得临床推广。

Objective To investigate the effect of rabeprazole in treating peptic ulcer with helicobacter pylori( HP) positive.Methods234 patients with peptic ulcer with HP infection from March 2013 to March 2015 in the hospital were randomly divided into the observation group and the control group.The observation group was given Rabeprazole,and the control group was given Omeprazole.Results 1 day after treatment,the remission rate of epigastric pain in observation group was 72.65%,which was obviously higher than 33.33% in the control group( P < 0.05); 1 week after treatment,the remission rate of epigastric pain in the observation group was 100.00%; 1 day after treatment,the clinical symptoms such as abdominal pain,belching,acid regurgitation,nausea etc.,were significantly improved in the two groups,and the observation group improved more significantly( P < 0.05); the healing time of ulcer and HP eradication in the observation group were significantly shorter than those in the control group,and the healing rate of ulcer in the observation group was 93.16%,which was significantly higher than 73.50% of the control group,and the eradication rate of HP in the observation group was 95.73,which was significantly higher than 78.63% in control group; the total effective rate in the observation group was 97.44%,which was significantly higher than 88.03% in the control group( P < 0.05); in the 1 year follow- up survey,the recurrence rate of ulcer and infection rate of HP in the observation group was significantly lower than those in the control group( P <0.05); and in two years of follow- up survey,the recurrence rate of ulcer and infection rate of HP in the 2 groups were increased,but the observation group still significantly lower than those in the control group( P < 0.05).Conclusion Rabeprazole for impoving positive HP peptic ulcer has better effect than omeprazole,which can relieve the clinical symptoms,increase the healing rate of ulcer,reduce the infection rate of HP,it is worthy of clinical promotion.