必需脂肪酸对脂肪组织生长、leptin浓度及免疫系统影响的研究进展

The advancement of the study on EFA for adipose tissue growth,leptin concentration and immune systems

围生期的营养因素可导致发育的适应,从而程序化地引起后期生命的病理性改变。妊娠期和哺乳期母亲摄入足够的必需脂肪酸(EFA),对胎儿及其生后的发育非常重要。在动物和人的研究中发现,EFA 和 n-6与 n-3多不饱和脂肪酸(PUFA)的不同比例,都将影响其后代的神经内分泌系统和免疫系统的生长发育,也可通过 leptin 相关机制影响其后代的后期生命。本文将着重论述 EFA 对脂肪组织生长、leptin 浓度和免疫系统影响的研究进展。

Nutritional factors during a sensitive perinatal period may lead to developmental adaptations pro- posed to programme for pathological conditions later in life.An adequate supply of essential fatty acids(E- FA)during pregnancy and lactation is crucial for optimal fetal and postnatal development.In animals and man, variations in the levels of EFA and in the ratio of n-6 to n-3 polyunsaturated fatty acids(PUFA)affect growth,developent of the neuroendocrine and the immune systems of the offspring and might also have addi- tional effects later in life via,for instance,leptin-associated mechanisms.The review will focus on the advance- ment of the study on EFA for adipose tissue growth,leptin concentration and immune systems.