膳食习惯、代谢综合征各要素与高尿酸血症的关系探讨

A relativity study of hyperuricemia with factors of dietary and metabolic syndrome

目的调查北京东城区部分常住居民高尿酸血症发生情况,分析与膳食、代谢综合征各要素关系。方法对2003～2004年参加糖尿病筛查者进行横断面调查,了解代谢综合征发生状况,并用半定量食物频度法调查富营养生活习惯。结果高尿酸血症发生率4.3%。其中女性1.07%,男性10.7%,双变量分析和秩和检验显示血甘油三酯、女性糖调节异常者与高尿酸血症显著相关(P<0.01),在男性则未见相关。logistic多元回归分析发现男性、肥胖、中心性肥胖、高酯血症与高尿酸血症的危险升高显著相关(P<0.01),HDL-C和空腹血糖则呈负相关。但经常食用肉汤、海鲜类、内脏、箘类等富嘌呤食物均未见明显相关。结论本调查中男性、肥胖、中心性肥胖、高酯血症等可能与高尿酸血症的危险性升高相关。

Objective To investigate the prevalence of hyperuricemia and its associated factors including dietary and metabolic syndrome in populations of Dongcheng district in Beijing.Methods A cross-sectional study of hyperuricemia was carried out in volunteers who had diabetes screening from 2003 to 2004.The prevalence of hyperuricemia was calculated in the population.Applying the form of food frequency to know the intake of nutritional-rich diet.Results The prevalence of hyperuricemia in this population was 4.3%,and in male and female were 10.7% and 1.07% respectively.Bivariate and rank analysis found that hypertriglyceride were associated with increased prevalence of hyperuricemia(P<0.01).There was significantly relativity with impaired glucose regulation in female,whereas no relativity in male.Multivariate logistic regression analysis found that male,obesity,waist obesity,hypertriglyceride,hypercholesterolemia were significantly associated with prevalence of hyperuricemia(P<0.01),HDL-c and fasting glucose were negative significantly association,but the products of nutrient buillon,seafood,animal organs,mushroom were no significantly associated whether men or women.Conclusions Male gender,obesity,waist obesity and hypercholesterolemia,hypertriglyceride may be associated with increased risk of hyperuricemia.