头孢克肟颗粒联合氨溴特罗口服液治疗门诊小儿肺炎的疗效观察

Observation on Efficacy of Cefixime Granules Combined with Ambroxol Oral Liquid in Treatment of Outpatient Pediatric Pneumonia

目的:探讨头孢克肟颗粒联合氨溴特罗口服液治疗门诊小儿肺炎的疗效。方法:选取2015年5月至2018年4月广州市花都区妇幼保健院(胡忠医院)门诊收治的小儿肺炎患者98例,随机分为对照组和观察组,每组49例。对照组患儿给予氨溴特罗口服液治疗,观察组患儿给予头孢克肟颗粒、氨溴特罗口服液联合治疗。观察两组患儿的临床疗效、不良反应发生情况及临床症状改善情况。结果:治疗后,观察组患儿的总有效率为95.9%(47/49),明显优于对照组的71.4%(35/49),差异有统计学意义(P<0.05);观察组、对照组患儿不良反应发生率分别为8.2%(4/49)、10.2%(5/49),差异无统计学意义(P>0.05);治疗后,观察组患儿发热、气促、咳嗽及肺部啰音消失时间明显短于对照组,差异均有统计学意义(P<0.05)。结论:头孢克肟颗粒联合氨溴特罗口服液治疗门诊小儿肺炎的疗效显著,能够在较短的时间内改善患儿多项症状,且不良反应少。

OBJECTIVE:To probe into the efficacy of Cefixime granules combined with ambroxol oral liquid in treatment of outpatient pediatric pneumonia.METHODS:98 children with pneumonia admitted into outpatients of Guangzhou Huadu District Maternal and Child Health Hospital(Huzhong Hospital)from May 2015 to Apr.2018 were extracted to be randomly divided into control group and observation group,with 49 cases in each group.Patients in the control group were treated with ambroxol oral liquid,while the observation group received Cefixime granules combined with ambroxol oral liquid.The clinical efficacy,adverse drug reactions and improvement of clinical symptoms of two groups were observed.RESULTS:After treatment,the total effective rate of the observation group was 95.9%(47/49),significantly better than that of the control group 71.4%(35/49),with statistically significant difference(P<0.05).The incidence of adverse drug reactions in the observation group and the control group was 8.2%(4/49)and 10.2%(5/49),respectively,and the difference was not statistically significant(P>0.05).After treatment,the disappearance time of fever,anhelation,cough and lung voice of the observation group was significantly shorter than that of the control group,and the difference was statistically significant(P<0.05).CONCLUSIONS:The efficacy of Cefixime granules combined with ambroxol oral liquid in treatment of outpatient pediatric pneumonia is significant,which can improve a variety of symptoms in a short period of time,with fewer adverse drug reactions.