574例药品不良反应报告

574 Cases of Adverse Drug Reactions

目的:探讨中山市东凤人民医院(以下简称"我院")药品不良反应(adverse drug reaction,ADR)发生的规律和特点,为临床安全用药提供参考。方法:对2013—2017年我院上报的574例ADR报告进行分类统计分析。结果:574例ADR中,男性患者271例,女性患者303例,男女之比为1∶1.12;>20～50岁患者最多,共353例(61.50%);引发ADR的主要给药途径为静脉滴注,共474例(占82.58%);新的ADR 136例(占23.69%),严重的ADR 35例(占6.10%);ADR涉及药物17类67个品种,主要为抗菌药物(470例,占81.88%),其次为中成药(44例,占7.67%)。ADR共累及器官和(或)系统606例次,主要累及皮肤及其附件(459例次,占75.74%)。结论:应全面加强ADR监测工作,保证临床用药安全、有效,促进临床合理用药。

OBJECTIVE:To investigate the occurrence laws and characteristics of adverse drug reactions(ADR)in Dongfeng Zhongshan People's Hospital(hereinafter referred to as“our hospital”),so as to provide reference for the safe medication in clinic.METHODS:Classified statistical analysis was conducted on 574 ADR reports reported by our hospital from 2013 to 2017.RESULTS:Of the 574 patients with ADR,271 were male and 303 were female,with a male to female ratio of 1∶1.12;patients aged>20 to 50 years old were the most,with a total of 353 cases(61.50%).The main route of administration for ADR was intravenous infusion,totally 474 cases(82.58%).There were 136 cases(23.69%)of new ADR,35 cases(6.10%)of severe ADR.ADR involved 17 categories and 67 kinds of drugs,mainly were antibacterial drugs(470 cases,81.88%),followed by Chinese patent medicine(44 cases,7.67%).A total of 606 case-times of ADR were involved in organs and(or)systems,mainly for the skin and its appendages(459 case-times,75.74%).CONCLUSIONS:ADR monitoring should be strengthened comprehensively to ensure the safety and effectiveness medication and promote the rational clinical medication.