头孢丙烯分散片致幼儿短暂幻视一例

One Case of Infantile Transient Vision Caused by Cefprozil Dispersible Tablets

1例5.2岁女性患儿,口服头孢丙烯分散片后约8 min诉双膝盖疼痛,约20 min后诉眼前可见红色方形、圆形物体,该幻觉持续1～2 min后消失;当日午夜,诉浑身瘙痒,可见皮肤潮红,予以抗过敏药(氯雷他定)口服;第2日,因发热予以退热药和头孢丙烯分散片,又诉眼前可见上述幻觉物体,立即停用头孢丙烯分散片,换用其他抗菌药物,后未再出现上述幻觉或类似症状。头孢丙烯可能引起儿童如幻视等精神病学反应,可能具有神经系统毒性。因此,儿童使用头孢丙烯时,需关注其神经系统不良反应,一旦发生,应停药并换用换用其他结构差异较大的抗菌药物或非头孢菌素类抗菌药物。

A 5.2-year-old female patient complained of pain in both knees about 8 min after oral administration of Cefprozil dispersible tablets.After 20 minutes,a red square or round object was visible in front of the patient's eyes,the hallucination disappeared after 1 to 2 min.At midnight of the same day,the patient complained of pruritus all over the body,and the skin was flushed,and antiallergic drugs(loratadine)were given orally.On the 2nd day,the antipyretic and the Cefprozil dispersible tablets were given due to the fever,and the above-mentioned hallucinogenic objects were seen in front of the eyes again.The Cefprozil dispersible tablets were immediately discontinued and replaced with other antibacterial drugs,and the above-mentioned hallucinations or the similar phenomenon did not occur again.Cefprozil dispersible tablets may cause psychiatric reactions in children such as hallucinations and may have neurotoxicity.Therefore,the use of cefprozil in children requires more attention to adverse neurological reactions.In the event of adverse drug reactions,the drug should be discontinued and replaced with other antibiotics with large structural differences or non-cephalosporin antibiotics.