儿童呼吸道感染病原体IgM抗体检测分析

The analysis of IgM antibodies in children with respiratory tract infection

目的分析昌平地区急性呼吸道感染(ARI)住院患儿病原体IgM抗体检测情况,为临床早期病原学诊断及合理用药提供依据。方法选取2O17年3月~2018年2月ARI住院患儿2069例作为研究对象,采用间接免疫荧光法检测患儿血清中8种常见病原体IgM抗体,并对上述病原谱、病原流行概况、病原阳性患儿年龄及性别分布特点进行临床流行病学资料汇总分析。结果 2069例ARI患儿中检测出病原体IgM抗体阳性630例,阳性率为30.5%,其中肺炎支原体(MP)阳性率最高,为12.9%,其次为副流感病毒(PIV)5.8%,乙型流感病毒(IVB)4.4%和甲型流感病毒(IVA)2.9%。各年龄组不同病原体的感染阳性率比较差异均有统计学意义,各年龄组病原体感染的总阳性率比较差异同样具有统计学意义。结论昌平地区ARI住院患儿主要病原体为MP、PIV、IVB、IVA;病原体感染在各年龄组患儿中存在差异。

Objective To analyze the situation of IgM antibody in hospitalized children with acute respiratory tract infection(ARI) in Changping. To provide evidence for early diagnosis and rational use of drugs in clinic.Method 2069 cases of ARI hospitalized children from March 2017 to February 2018 were selected as the research objects. Indirect immunofluorescence assay was used to detect 8 common pathogens IgM antibodies in sera ofchildren. Clinical epidemiological data were collected and analyzed.Result In 2069 cases of ARI, 630 cases of IgM antibody positive were detected. The positive rate was 30.5%. The highest positive rate of pathogen was mycoplasma pneumoniae(MP), was 12.9%. Followed by parainfluenza virus(PIV) 5.8%, influenza B virus(IVB) 4.4% and influenza A virus(IVA) 2.9%. The positive rates of infection among different age groups were statistically significant. The total positive rate was also statistically significant. Conclusion The main pathogens of ARI hospitalized children in Changping are MP, PIV, IVB and IVA. There are differences in pathogen infection among children in all age groups.