蛛网膜下腔出血后脑血管痉挛在血管病理性改变中的作用

Effects of cerebral vasospasm following subarachnoid hemorrhage to pathological changes in vessel wall.

目的:探讨蛛网膜下腔出血(SAH)性脑血管痉挛(CVS)与血管壁病理学改变之间的因果关系。方法采用药理学预阻滞法,利用光镜和电镜对猫SAH后CVS的形成及其对血管壁病理性改变的影响作用进行了观察。结果预先使用血管外周阻滞剂可以明显地减轻SAH所致的CVS反应程度,并使血管壁发生的病理性改变也随之轻化,从而提示CVS是血管壁发生病理性改变的成因,继而是影响SAH预后的主要原因之一。结论SAH性双期CVS是导致痉挛的血管壁发生病理学改变的主要原因之一,有效地预防或阻止CVS的发生,便可以有效地防止血管壁发生的相应病理学改变,这为确认阻止CVS的发生是SAH救治关键奠定了理论基础。

Objective To evaluate the relation of cerebral vasospasm(CVS)following subarachnoid hemorrhage(SAH)to pathological changes in vessel wall.Methods To take pharmacological block method and with photo-electronic microscopy to observe the emergence and effect of cerebral vasospasm(CVS)following SAH to pathological changes in vessel wall in cats.Results Prophylactic use of paravasospam antagonist may reduce obviously reacting extent of CVS following SAH and the pathological changes of the wall.This represents CVS is one of main causes of the pathological changes that affects prognosis of SAH.Conclusion The one of main causes of pathological changes of the wall is bi-stages CVS following SAH.Effectively to prevent and block CVS would prevent effectively the pathological changes of the wall,which lay the theoretic groundwork that control of CVS is the key of cure for SAH.