冠心病患者血尿酸、超敏C反应蛋白、总胆红素以及直接胆红素的表达及意义

Value of uric acid and high sensitive C reactive protein in blood, serum total bilirubin and direct bilirubin in patient with coronary heart disease

目的分析冠心病患者血液中尿酸、超敏C反应蛋白、血清总胆红素以及直接胆红素检验的临床价值。方法对济南市长清区万德中心卫生院收治的122例冠心病患者(试验组)和106例健康体检者(对照组)实施血生化检查,观察两组尿酸(UA)、超敏C反应蛋白(hs-CRP)、血清总胆红素(TBIL)及直接胆红素(DBIL)水平,并进行比较。采用SPSS 18.0统计软件进行数据分析,计量资料以(xˉ±s)表示,组间数据对比应用t检验,P<0.05为差异有统计学意义。结果试验组血UA水平及hs-CRP水平均高于对照组,差异有统计学意义(P<0.05);试验组血清TBIL及DBIL水平则低于对照组,差异有统计学意义(P<0.01)。结论冠心病患者UA、hs-CRP、血清TBIL及DBIL等的水平变化提示其病情的演变,临床干预时参考以上指标可以更精准地评估病情,实现早期诊断,并实施有效地治疗方案以改善患者的预后。

Objective To analysis the value of uric acid and hypersensitive C-reactive protein in blood,serum total bilirubin and direct bilirubin in patients with coronary heart disease(CHD). Methods A total of 122 patients with CHD were selected as experimental group and 106 healthy persons were select as control group. The levels of uric acid(UA) and hypersensitive C-reactive protein(hs-CRP) and serum total bilirubin(TBIL) and direct bilirubin(DBIL) in the two groups were examined and compared. Results The blood levels of UA and hs-CRP in the experimental group were higher than those in the control group(P<0.05), and the serum levels of TBIL and DBIL in experimental group were significantly lower than those in the control group(P<0.01). Conclusions The levels of UA, hsCRP, TBIL, DBIL were closely related with the evolution of CHD. Doctors in clinical intervention refer to the above indexes can more accurately evaluate the disease, early diagnosis, implement effective treatments to improve the prognosis of patients.