2种输血方法治疗尿毒症透析患者贫血的效果比较

The comparison of effect of transfusion when dialysis and transfusion after dialysis in the treatment of uremia patient with anemia

目的比较透析期和透析后输血治疗尿毒症透析患者贫血的治疗效果,指导临床安全有效治疗。方法选择广州医科大学附属第一医院2013年1~12月收治的60例尿毒症透析贫血患者,按随机数字表分为A组(30例)和B组(30例),A组患者在透析3 h输注红细胞悬液2 U,B组患者在透析完成后2 h输注洗涤红细胞2 U,治疗前后采用全自动干式生化分析仪测定血清尿素氮(BUN)、肌酐(CREA)、K+,采用血细胞计数仪测定血清血红蛋白(Hb)水平。结果 A组和B组治疗后Hb水平均较治疗前升高(P均<0.05),2组间差异无统计学意义(P>0.05)。A组和B组治疗后血清BUN、CREA均较治疗前降低(P均<0.05),2组间比较差异均无统计学意义(P均>0.05)。2组治疗前后组内及组间血清K+差异均无统计学意义(P均>0.05)。结论透析期和透析后输血治疗尿毒症透析患者贫血安全、有效,透析期输血可选择红细胞悬液,非透析期最好选择洗涤红细胞。

Objective To compare the effect of transfusion when dialysis and transfusion after dialysis in the treatment of uremia patient with anemia, and to guide safe and effective clinical treatment. Methods A total of 60 patiens with anemia from 2013 January to 2013 December were chosen as test object, all patients were randomly divided into group A and group B.Group A were given erythrocytes 2 U when dialysis 3 h, and group B were given washed red blood cells 2 U after dialysis 2 h. The BUN,CREA, K+were determined by automatic dry biochemical analyzer, the Hb was detected by automatic blood cell analyzer. Results The levels of Hb after treatment in two groups were all higher than those before treatment(all P<0.05), the difference between the two groups was not significant(P>0.05). The levels of BUN and CREA after trentment in two groups were all lower than those before treatment(all P<0.05), but there were no significant differences between the two groups(all P>0.05). The levels of K+had no significant differences before and after treatmen in two groups. Conclusions Transfusion with erythrocytes when dialysis and transfusion with washed red blood cells after dialysis are all safe and effective methods in the treatment of patient with anemia.