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从胆固醇代谢特点论降胆固醇药物联合应用 被引量:2

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摘要 胆固醇是血脂干预的首要目标[1]。他汀类药物治疗,通过大幅降低血清总胆固醇,特别是低密度脂蛋白胆固醇(LDL-C)水平,可显著降低动脉粥样硬化性心血管疾病(ASCVD)发病率和死亡率[2],故被国内外指南推荐为ASCVD一级、二级预防的一线用药[3-7]。然而临床实践中,一部分患者应用常规甚至较大剂量他汀单药治疗后,仍不能实现血脂达标,剂量倍增后不仅降脂疗效有限,同时也会带来成本和不良反应的增高[8,9]。
出处 《慢性病学杂志》 2015年第3期240-244,共5页 Chronic Pathematology Journal
基金 国家自然科学基金面上项目(81170266) 北京市优秀人才培养资助青年拔尖个人项目(2014000021223ZK29)
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