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2型糖尿病患者并发血管病变的综合因素分析 被引量:2

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摘要 目的探讨生化及免疫因素与糖尿病血管性并发症的发生与发展的相关性。方法选择临床78例病程超过2年的2型糖尿病患者和15例健康对照者(对照组),2型糖尿病患者通过B超检测的颈动脉内膜中层厚度(IMT)分组:IMT正常组(25例)、IMT增厚组(27例)、颈动脉斑块形成组(26例),分别进行相关生化指标和免疫分子水平的检测。运用Kruskal-Wallis秩和检验进行四组间的比较,组间差异通过Wilcoxon’s秩和检验,P<0.05为差异有统计学意义。结果 78例受试者中IMT增厚组和颈动脉斑块形成组的生化指标血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和免疫指标血管内皮生长因子(VEGF)、血小板衍生生长因子(PDGF)、白介素-6(IL-6)检测值均高于15例正常健康对照组,差异有统计学意义(P<0.05)。结论生化指标TC、TG、LDL-C和免疫分子VEGF、PDGF、IL-6与糖尿病并发血管病变具有一定的相关性。
出处 《慢性病学杂志》 2016年第2期164-166,共3页 Chronic Pathematology Journal
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