生长分化因子-15与冠心病病变程度的相关性研究被引量：3

Correlation between the serum growth differentiation factor-15 levels and the severity of coronary artery lesion in patients with coronary heart diseases

原文传递

导出

摘要目的探讨冠心病(CHD)患者血清生长分化因子-15(GDF-15)与冠状动脉病变严重程度的关系。方法选择经冠状动脉造影(CAG)检查确诊为CHD的患者150例作为研究对象,另选经冠状动脉造影检查确诊为非CHD的健康人群30例作为对照组,以Gensini积分评价冠状动脉病变程度,采用ELISA法测定血清GDF-15水平。结果 CHD患者血清GDF-15水平高于对照组;随着冠状动脉病变支数的逐渐增加,CHD患者Gensini积分与GDF-15水平呈正相关;线性回归分析显示两者具有线性关系。结论血清GDF-15水平与冠状动脉病变程度密切相关,GDF-15水平可作为CHD患者冠状动脉病变程度的一个预测指标。 Objective To investigate the relationship between the serum levels of growth differentiation factor-15(GDF-15) and the severity of coronary artery lesion in patients with coronary heart disease.Methods Totally 150 patients with coronary heart diseases diagnosed by coronary angiography examination were included in the study,and 30 cases of healthy people were acted as control group.The severity of coronary artery lesion was assessed by Gensini score.ELISA method was used to detect serum GDF-15 concentration.Results The serum level of GDF-15 in patients with coronary heart diseases was higher than that in the control group.With the gradual increase of coronary artery lesion counts,the serum level of GDF-15 was positively correlated with Gensini score.They were demonstrated to have linear relationship by linear regression analysis.Conclusions The serum levels of GDF-15 and the severity of coronary artery lesion in patients with coronary heart diseases are closely related,and it can be used as a predictor of the severity of coronary artery lesion in patients with coronary heart disease.

作者田立超刘杰赵力欣王伟王志军

机构地区华北理工大学附属医院心内科

出处《慢性病学杂志》 2016年第4期387-390,共4页 Chronic Pathematology Journal

基金河北省卫生和计划生育委员会科研基金项目(20100474)

关键词冠心病生长分化因子-15 GENSINI积分冠脉病变程度 Coronary heart disease Growth differentiation factor-15 Gensini score Severity of coronary artery lesion

分类号 R541.4 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献1

1郑凌冰,郭艳红,于海奕,米琳,汪宇鹏,高炜.血清生长分化因子-15与急性冠状动脉综合征的相关性分析[J].北京大学学报（医学版）,2011,43(2):250-254. 被引量：28

二级参考文献11

1Ago T,Sadoshima J.GDF-15,a cardioprotective TGF-β superfamily protein[J].Circ Res,2006,98 (3):294-297.
2Azhar M,Schultz Jel J,Grupp I,et al.Transforming growth factor-beta in cardiovascular development and function[J].Cytokine Growth Factor Rev,2003,14(5):391 -407.
3Kempf T,Eden M,Strelau J,et al.The transforming growth factor-beta superfamily member growth differentiation factor-15 protects the heart from ischemia/reperfusion injury[J].Circ Res,2006,98(3):351 -360.
4Wollert KC,Kempf,Peter T,et al.Prognostic value of growth differentiation factor-15 in patients with non-ST elevation acute coronary syndrome[J].Circulation,2007,115(8):962 -971.
5Xu J,Thomas R,Kimball JN,et al.GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with smad protein activation[J].Circ Res,2006,98 (3):342-350.
6Khan S,Dhillon K,Kelly D,et al.Growth differentiation factor15 as a prognostic marker in patients with acute myocardial infarction[J].Eur Heart,2009,30(9):1057 -1065.
7Kempf T,Bj(o)rklund E,Olofsson S,et al.Growth differentiation factor-15 improves risk stratification in ST-segment elevation myocardial infarction[J].Eur Heart,2007,28(23):2858 -2865.
8Wollert KC,Kempf T,Lagerqvist B,et al.Growth differentiation factor-15 for risk stratification and selection of an invasive treatmert strategy in non-ST elevation acute coronary syndrome[J].Circulation,2007,116 (14):1540-1548.
9Brown DA,Breit SN,Buring J,et al.Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular enents in women:a nested case control syudy[J].Lancet,2002,359(9324):2159 -2163.
10Kempf T,Hom-Wichmann R,Brabant G,et al.Circulating concentrations of growth differentiation factor-15 in apparently healthy elderly individuals and patients with chronic heart failure aa assessed by a new immunoradiometric sandwich assay[J].Clin Chem,2007,53(2):284 -291.