血清LDL-C/HDL-C比值与原发性高血压分级的相关性分析

Correlation analysis of essential hypertension grade and the ratio of serum LDL-C/HDL-C

目的探讨血清低密度脂蛋白胆固醇(LDL-C)与高密度脂蛋白胆固醇(HDL-C)比值与原发性高血压(以下简称高血压)分级的关系。方法随机抽取新诊断的高血压患者150例,分为1级、2级、3级高血压组,每组50例,另取50例血压正常者作为对照组,分别测定每组对象的血压、体质量、身高、血清甘油三脂(TG)、总胆固醇(TC)、LDL-C、HDL-C水平,计算LDL-C/HDL-C比值,并进行组间比较。各项血脂指标与血压水平及高血压分级的相关性采用Pearson相关分析。结果四组对象的血脂指标比较差异有统计学意义(P<0.05);Pearson相关分析显示,TG、TC、LDL-C水平、LDL-C/HDL-C比值分别与收缩压、舒张压、高血压分级呈正相关,HDL-C水平分别与收缩压、舒张压、高血压分级呈负相关,均P<0.05。LDL-C/HDL-C比值与高血压分级的相关系数的绝对值更接近1,相关性更强。结论血清LDL-C/HDL-C比值与原发性高血压分级的相关性较单项血脂指标更强。

Objective To investigate the relationship between essential hypertension grade and the ratio of serum low density lipoprotein cholesterol(LDL-C) to high density lipoprotein cholesterol(HDL-C). Methods A total of 150 newly confirmed hyperpietic were randomly selected and divided into level 1, level2, level 3 group, 50 cases in each group. Totally 50 individuals without hypertension were selected as the control group. Blood pressure, body mass index(BMI), serum triglyceride(TG), total cholesterol(TC), LDL-C, HDL-C, LDL-C/HDL-C of four groups were measured and compared. The relationship between above indexes and essential hypertension grade were analyzed by Pearson correlation analysis method. Results The levels of TG, TC, LDL- C and HDL- C between the four groups were significantly different(P<0.05). TG, TC, LDL-C and LDL-C/HDL-C were positively correlated with essential hypertension grade, systolic blood pressure(SBP) and diastolic blood pressure(DBP); HDL- C was negatively correlated with essential hypertension grade, SBP and DBP(all P<0.05). The absolute value of correlation coefficient between LDL-C/HDL-C and essential hypertension grade was more close to 1,so the correlation was stronger. Conclusions The correlation between LDL-C/HDL-C and essential hypertension grade is stronger than other single lipid indexes.