芪仙汤联合美沙拉嗪治疗溃疡性结肠炎疗效研究

Study on the therapeutic effect of Qixian decoction combined with mesalazine on ulcerative colitis

目的探讨中西医结合治疗溃疡性结肠炎(UC)的方案和效果。方法选取2016年1月至2017年1月滕州中心人民医院肛肠科收治的UC溃疡性结肠炎患者100例,采用数字表法随机分为观察组和对照组,每组50例。对照组患者予以美沙拉嗪治疗,观察组采用芪仙汤联合美沙拉嗪治疗,治疗6~12周结束时比较两组的临床治疗效果,并观察患者临床症状及病理特征的变化。结果观察组治疗的总有效率88.00%,明显高于对照组的64.00%;复发率8.00%,明显低于对照组的52.00%;观察组患者腹痛、腹泻和血便等症状评分分别为(0.96±0.05)分、(1.02±0.09)分和(0.91±0.12)分,分别明显低于对照组的(2.35±0.44)分、(2.73±0.38)分和(2.04±0.36)分;观察组患者的溃疡、水肿、糜烂、出血等肠黏膜病理改善率分别为84.00%、82.00%、90.00%、88.00%,明显高于对照组的66.00%、58.00%、48.00%和50.00%;观察组结肠镜评分(0.64±0.41)分,明显低于对照组的(1.37±0.58)分。上述差异均有统计学意义(均P<0.05)。结论芪仙汤联合美沙拉嗪治疗UC患者临床疗效确切。

Objective To investigate the clinical efficacy of combination therapy of traditional Chinese medicine and western medicinein the treatment of ulcerative colitis(UC). Method A total of 100 UC patients were selected from Tengzhou Central People's Hospital from January 2016 to January2017, and they were randomly divided into the observation group and the control group, 50 cases in each group. The control group was treated with mesalazine, and the observation group was treated with Qixian decoction combined with mesalazine. After treatment for 6 to 12 weeks, clinical curative effect of two groups were compared, and the changes of clinical symptoms and pathological characteristics were observed. Results The total effective rate in the observation group was significantly higher than that in the control group(88.00% vs. 64.00%); the recurrence rate in the observation group was lower than that in the control group(8.00% vs. 52.00%); the abdominal pain, diarrhea and bloody stool symptom scores in the observation group were significantly lower than thosein the control group(0.96±0.05 vs. 2.35±0.44, 1.02±0.09 vs. 2.73±0.38, 0.91±0.12 vs. 2.04±0.36); intestinal mucosal pathological improvement rate of ulcer, edema, erosion, bleeding in the observation group were significantly higher than those in the control group(84.00% vs. 66.00%, 82.00% vs. 58.00%, 90.00% vs.48.00%, 88.00% vs. 50.00%); colon mirror score in the observation group was significantly lower than that in the control group(0.64±0.41 vs. 1.37±0.58). The above differences were statistically significant(all P<0.05). Conclusion Qixian decoction combined with mesalazine has definite curative effect for the treatment of UC patients.