宁波市职业人群高尿酸血症与心血管疾病危险因素关系研究

RELATIONSHIP BETWEEN HYPERURICEMIA AND CARDIOVASCULAR DISEASE RISK FACTORS AMONG PROFESSIONAL PEOPLE IN NINGBO

目的了解宁波市职业人群高尿酸血症(HUA)检出情况,分析HUA与心血管疾病危险因素的相关性。方法收集2017年在宁波市某医院健康体检的年龄18~60岁的职业人群资料,分析HUA患病情况,并用Logistic回归分析心血管疾病危险因素相关健康指标与尿酸水平的关系。结果 4548位体检人群中,高尿酸血症检出1367例,患病率为30.06%,其中男性42.59%,女性12.55%,男性HUA患病率高于女性(P<0.05)。不同年龄、职业人群的尿酸水平和HUA患病率比较差异有统计学意义(P<0.05)。Logistic回归分析结果显示,年龄、高密度脂蛋白胆固醇(HDL-C)和空腹血糖(FBG)是男性患HUA的保护因素,收缩压(SBP)、总胆固醇(TC)、甘油三酯(TG)是危险因素;女性中,年龄、HDL-C和FBG也是HUA的保护因素,舒张压(DBP)、体质指数(BMI)、TC、TG是危险因素。结论体检人群中HUA的检出率较高,HUA患病率有年轻化趋势,商业服务业人群HUA的患病率较高,HUA与心血管疾病危险因素关联性较强,应根据不同年龄、职业及身体健康指标进行针对性健康及膳食指导,以预防和控制HUA及心血管疾病。

Objective To understand the prevalence of hyperuricemia(HUA)among working population and explore the associations between HUA and the risk factors of cardiovascular disease.Methods A cross-sectional survey was conducted in 2017 by health examination in the people aged between 18 and 60 years old in a hospital of Ningbo.The prevalence of HUA was analyzed.The Logistic regression was used to explore the association of risk factors of cardiovascular disease with uric acid.Results A total of 4548 subjects were enrolled in this study,and the prevalence of HUA was 30.06%(1376/4548).The condition was more common in men than in women(42.59%vs12.55%,P<0.05).There were statistically significant differences by age and occupation in uric acid levels and the prevalence of HUA(P<0.05).Logistic regression analysis showed that the age,high density lipoprotein-cholesterol(HDL-C)and fasting plasma glucose(FBG)were protective factors of HUA.Systolic blood pressure,total cholesterol and triglyceride were independent risk factors of HUA among men,while diastolic blood pressure,body mass index,total cholesterol and triglyceride were risk factors of HUA among women.Conclusion The prevalence of HUA in working population was high and showed a younger trend.Commercial service people had a higher prevalence of HUA.HUA and the risk factors of cardiovascular disease were closely related.Targeted health intervention and dietary guidance according to different age,occupation and health indicators are needed to prevent and control HUA and cardiovascular disease.