胃癌的危险因素调查及癌前病变动态观察

AN INVESTIGATION OF THE RISK FACTORS AND THE DYNAMIC OBSERVATION ON THE PRECANCEROUS PATHOLOGICAL CHANGES

报道温州地区胃癌高发区瑞安塘下的致癌危险因素的调查情况,结果表明它是由多种致癌危险因素的综合影响。作者应用内镜活检在18000例慢性胃病患者中查出癌前病变(高危人群)1132例,经3月～14年活检随访,表明胃癌前病变有一定的可逆转性;癌变率较高的是胃溃疡(GU)+不典型增生(ATP)组、GU+慢性萎缩性胃炎(CAG)组及CAG+ATP组均为4.1％;总癌变率为3.1％。早癌检出率占胃癌总数的48.6％,为门诊早癌检出率的6.8倍。此方法简单、经济实用。

The investigation of the carcinogenic risk factors is reported at Tangxia of Ruian city in Wenzhou district, where the morbidity of stomach cancer is fairly high. The results show that many carcinogenic risk factors are responsible for the stomach cancer. 18000 patients with chronic stomach lesion are examined with endoscopy and biopsy of whom 11320 are diagnosed as precancerous lesion (high risk population). The follow-up by biopsy for 3 months to 14 years shows that the precancerous lesion is reversible in some cases. The higher cancerization is found in the groups of gastric ulcer ( GU ) ' plus atypical hyperplasia (ATP), gastric ulcer plus chronic atrophic gastritis (CAG) and CAG plus ATP, with the rate of 4.1% resp-eclively. The total cancerization rate is 3.1% and the early cancer accounts for 48.6%, 6.8 times higher than that diagnosed in the out-patient department. This method is simple, economical and practical.