大川芎方对偏头痛大鼠神经细胞凋亡的影响

Effect of Dachuanxiong Prescription on nerve cell injury of migraine rat

目的 :研究大川芎方 (天麻、川芎等 )对偏头痛大鼠神经细胞凋亡的影响。方法 :采用硝酸甘油偏头痛模型大鼠 ,运用透射电镜和流式细胞仪技术进行研究。结果 :大川芎方可以改善硝酸甘油型偏头痛大鼠神经细胞超微结构异常 ,降低总体凋亡发生率 ,降低神经细胞凋亡百分率。结论 :说明大川芎方对硝酸甘油型偏头痛大鼠神经细胞凋亡具有抑制作用。

Objective: To study the effects of Dachuanxiong Prescription(Rhizoma Gastrodiae, Rhizoma Chuanxiong, etc.) on nerve cell apoptosis of migraine model rat. Methods : To choose disease model of migraine with nitroglycerin by means of flow cytometry and transmission electron microscope. Results : Dachuanxing Prescription can adjust the abnormal ultra-structure of nerve cell of migraine model rats, decrease the incidence and the apoptosis percentage. Conclusion : Dachuanxing Prescription can block the nerve cell apoptosis of migraine model rat.