过硼酸钠氧化硫醚生成砜

CHEMOSELECTIVE OXIDATION OF ORGANIC SULFIDES TO SULFONES WITH SODIUM PERBORATE

过硼酸钠是一种价廉易得的氧化剂,近来受到不少人的注意。为了探讨这种试剂能否用于使带有羟基、羰基、酯基、酰胺基和氰基的硫醚选择氧化生成相应的砜,我们合成了一系列硫醚(1_(a-m)),并研究了它们在冰醋酸中与过硼酸钠的反应。

Phenylsulfides were readily oxidized by sodium perborate(NaBO3·4H2O) in glacial acetic acid medium to the corresponding sulfones in good to excellent yields. The reaction may be used in the presence of various other functional groups such as OH, COCH3, CO2CH3, CONH2 as well as cyano to give only sulfide oxidation.