阳离子抗菌肽研究进展

Research advances in cationic antimicrobial peptides

阳离子抗菌肽广泛分布于多种生物 ,越来越多的证据表明它们在机体天然免疫中有着重要的作用。广谱抗菌、抗病毒、抗肿瘤细胞及其它特性也使得其具有潜在的医药价值。对抗菌肽的研究正不断深入。该文从一般性质、作用机制、构效关系、重组表达、应用价值、存在的问题与发展方向等方面 。

Cationic antimicrobial peptides are found in diverse species. More and more evidence indicates their important role in innate immunity. Their broad spectrum activity against pathogenic bacteria,fungi,parasites,viruses or tumor cells,as well as some other properties,also make them attractive candidates for drug development. Continuing researches are developing clearer understanding of cationic antimicrobial peptides. This review focuses on the recent progress in the study of cationic antimicrobial peptides with respect to the general properties,mode of action,structure function relationships,recombinant production,therapeutic potential,and some existing problems etc.