缺血性脑血管病患者血浆肾上腺髓质素与内皮素的测定及其临床意义

The detection of plasma Adrenomedullin and endothelin levels in patients with ischemic cerebrovascular disease and its clinical significance

目的 监测缺血性脑血管病患者血浆肾上腺髓质素 (ADM)含量变化及其与血浆内皮素 (ET- 1)的关系 ,探讨其在缺血性脑血管病发生发展中的作用及其临床意义。方法 应用放射免疫法测定 88例缺血性脑血管病患者 (包括 4 0例脑梗死和 4 8例腔隙性脑梗死 )和 4 5例正常对照者的血浆 ADM和 ET- 1含量。结果 缺血性脑血管病组患者血浆 ADM含量及 ET- 1含量均高于正常对照组含量 (P<0 .0 5 ) ;脑梗死组血浆 ADM水平高于腔隙性脑梗死组的水平 (P<0 .0 5 ) ;缺血性脑血管病组血浆 ADM水平与血浆 ET- 1呈显著正相关 (r=0 .5 85 ,P<0 .0 5 )。结论 肾上腺髓质素参与了缺血性脑血管病的发生发展过程 ,可能对缺血性脑组织有保护作用。

Objective To investigate the changes of adrenomedullin (ADM) and endothelin-1(ET-1) levels in patients with ischemic cerebrovascular disease and discuss its meaning.Methods Plasma concentrations of ADM and ET-1 in 88 patients with ischemic cerebrovascular disease and 45 normal control were measured by radioimmunoassay.Results Plasma concentrations of ADM and ET-1 in ischemic cerebrovascular disease were significantly higher than those of control group (P<0.05).Both plasma ADM and ET-1 levels in patients with cerebral infarction were significantly higher than those of patients with lacunar infarction (P<0.05).The plasma concentrations of ADM in patients with ischemic cerebrovascular disease showed a significantly positive correlation with the plasma concentration of ET-1 (r=0.585,P<0.01).Conclusions ADM maybe play an important protective role in the pathogenesis of cerebral infarction. The increasing of plasma ADM levels in cerebral infarction patients correlated with the increasing of ET-1 levels.The plasma ADM levels maybe reflect the degree of endothelial injury.