肺肉芽肿性炎症FDG摄取特点初步研究

Fluorine-18 fluorodeoxyglucose uptake in granuloma of the lung

目的 初步探讨肺部肉芽肿性炎症对18氟脱氧葡萄糖 (FDG)的摄取特点。方法 对 2 0 0 0年 2月至 2 0 0 2年 4月间 12例肺部肉芽肿性炎症病人的FDG -正电子发射体层显像 (PET)检查资料进行分析 ,测取病变的最大与平均标准摄取值 (SUVmax与SUVmean) ,及正常肺组织的SUV(SUVlung)。 7例结核性肉芽肿 ,5例炎性假瘤均手术切除确诊。结果 肉芽肿性炎症病变的FDG摄取均高于相应的正常肺组织 (P <0 0 0 1)。SUVmax、SUVmean和SUVlung分别为 3 30± 1 77、2 5 8± 1 2 7和 0 40± 0 0 7。肉芽肿性炎症SUV与病变的最大直径正相关 (P <0 0 5 )。 6例病变的SUVmean与SUVmax均高于 2 5。结论 肺部肉芽肿性炎症的FDG摄取高于正常肺组织。肉芽肿性炎症病变的范围与SUV有正相关性。5 0 %的肺部肉芽肿性炎症的SUV高于 2 5 ,造成了FDG PET检查中的假阳性病例。

Objective: To assess the peculiarity of fluorine-18 fluorodeoxyglucose (FDG) uptake in pulmonary granuloma. Methods: From February, 2000 to April, 2002, 12 patients with pulmonary granuloma were imaged with FDG-PET (positron emission tomography) before surgery. The maximum and mean standard uptake value (SUVmax and SUVmean) of granuloma were measured and compared with SUV of normal lung (SUVlung). Results: All pulmonary granulomas were detected by FDG-PET. FDG uptake of granuloma was higher than that of normal lung (P<0 001). SUVmax, SUVmean and SUVlung were 3 30±1 77, 2 58±1 27 and 0 40±0 07, respectively. Correlation were found between FDG uptake and granuloma size (P<0 05). SUVmax and SUVmean in 6 granulomas (6/12, 50 0%) were higher than 2 5. Conclusion: (1)SUV was higher in granuloma than that in normal lung tissue. (2)FDG uptake is correlated with granuloma size.(3)50 percent of granulomas may be misdiagnosed as malignant tumor and this may relate to its higher FDG uptake.