氧头孢烯类抗生素对产超广谱β内酰胺酶菌株的体外抗菌活性研究

In vitro antibacterial activity of oxacephems to clinical isolates producing extended-spectrum β-lactamases

目的 :测定氧头孢烯类抗生素对产超广谱 β内酰胺酶 (ESBLs)菌株的体外抗菌活性。 方法 :采用E试验及琼脂稀释法测定亚胺培南、拉氧头孢、氟氧头孢、头孢噻肟等 9种抗菌药物对北京和杭州两地临床分离到的 98株ESBLs基因型明确的大肠埃希菌和肺炎克雷伯菌的最低抑菌浓度 (MIC)。结果 :产ESBLs菌株 ,对亚胺培南敏感率最高 (1 0 0 % ) ,其次为拉氧头孢(99.0 % )、氟氧头孢 (98.0 % ) ,头孢他啶的敏感率为 74 .5 % ,其余 5种抗菌药物活性较差。结论 :氧头孢烯类抗生素对产ES

Objective: To investigate the in vitro activity of oxacephems against extended spectrum β lactamases(ESBLs) producing strains. Methods:A total of 98 of Escherichia coli and Klebsiella pneumoniae ESBLs producing strains were collected from Beijing and Hangzhou hospitals, and the genotypes of ESBLs were detected. The minimum inhibitory concentrations(MIC) of moxalactam, flomoxef on these strains were determined by agar dilution method, and the MICs of the other antibiotics were determined by E test method. Results:Imipenem is still the most active agent (100%) against ESBLs producing strains, followed by moxalactam(99.0%), flomoxef(98.0%) and ceftazidime(74.5%). Conclusions:Oxacephems had good in vitro activity against ESBLs producing strains.