重组牛碱性成纤维细胞生长因子治疗放射性口腔反应的疗效

Clinical effectiveness of recombinant basic fibroblast growth factor in treatment of patients with oral cavity radiomucitis

目的:观察重组牛碱性成纤维细胞生长因子(rbFGF)对放射性口腔粘膜反应的预防和治疗作用。方法:放射治疗 头颈部肿瘤病人60例,随机分成治疗组和对照组各30例,开始放疗1周后,治疗组每日3次饭后口腔内喷雾贝复济5次约1 ml。对照组用生理盐水500 ml加庆大霉素4×105U,3次/d,饭后含漱,直至放疗结束。放疗开始和结束时验血测生化指标。结果:治疗组口腔粘膜放射反应轻于对照组口腔粘膜放射反应,且有统计学意义。结论:rbFGF能减轻放射性口腔粘膜反应,且安全可靠。

Objective: To observe clinical effectiveness of recombinant basic fibroblast growth factor (rbFGF) in treatment of patients with oral cavity radiomucitis. Methods: Sixty patients with head and neck carcinoma were randomly divided into the treating group and control group. One week after beginning of radiotherapy, the patients of treating group were given 1 ml of rbFGF by oral spraying after meal 3 times daily and the patients of control group gargled with 500 ml of saline plus gentamicin 4×105U after meal 3 times daily. Results: The oral cavity radiomucitis of treating group was milder than that of control group, with statistically significant difference in damage degree between 2 groups. Conclusion: The oral cavity radiomucitis can be treated with rbFGF.