醒脑启智胶囊对血管性痴呆小鼠学习记忆障碍的影响

The effect of Xingnaoqingzhi Capsule (醒脑启智胶囊) on study and memory retention disorder of vascular dementia mouse

目的 :观察醒脑启智胶囊对血管性痴呆学习记忆障碍小鼠的影响。方法 :复制脑缺血再灌注血管性痴呆小鼠模型 ,分别于术后 7天、15天、3 0天采用跳台法检测各组小鼠行为学变化。结果 :造模小鼠学习与记忆能力下降 ,表现为学习反应时间延长 ,记忆潜伏时间缩短 ,错误次数增加。醒脑启智胶囊可使模型小鼠学习反应时间缩短 ,记忆潜伏时间延长 ,错误次数减少。结论 :醒脑启智胶囊对模型小鼠学习与记忆能力下降有显著改善作用。

Objective: To observe the effect of Xingnaoqingzhi Capsule on study and memory retention disorder of vascular dementia mouse.Methods: To reproduct the mouse model of vascular dementia through operation of cerebral ischemia reperfusion, to detect the praxiological changes of mouse by means of jumping stand on the 7th,15th,and 30th day after operation. Results: Building model resulted in ability for study and memory reduced, which showed extending the reaction time of study, shorting the latent time of memory, increasing times of mistakes. Xingnaoqizhi Capsule could shorten the reaction time of study, prolonged latent time of memory, reduced times of mistakes. Conclusion: Xingnaoqizhi Capsule can improve and raise the study and memory capability of model mouse.