珍珠梅提取物对肝脏癌前病变大鼠体内自由基的清除作用

Effect of Sorbaria Sorbifolia extract on free radical metalism during precarcinogenesis induced by diethylnitrosamine in rats

[目的 ]探讨珍珠梅乙酸乙酯提取物对二乙基亚硝胺致肝脏癌前病变大鼠体内自由基的影响 .[方法 ]给动物灌胃给药 ,用二乙基亚硝胺制备大鼠肝脏癌前病变模型 .用比色分析法测定大鼠血清及肝匀浆中的超氧化物歧化酶、谷胱甘肽过氧化物酶的活性和丙二醛、谷胱甘肽的含量 .[结果 ]珍珠梅乙酸乙酯提取物能显著提高肝脏癌前病变大鼠血清及肝匀浆中的超氧化物歧化酶和谷胱甘肽过氧化物酶的活性 ,增高谷胱甘肽含量 ,降低丙二醛的含量 .[结论

OBJECTIVETo study the effect of Sorbaria Sorbifolia extract on free radical in precarcinogenesis induced by diethylnitrosamine in rats.?METHODS? Sorbaria Sorbifolia was perfused into stomach of rats with DEN induced precarcinogenesis, and it was detected by colorimetric method that the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH PX), and the concentrations of malondialdehyde (MDA), glutathione (GSH).?RESULTS? Sorbaria Sorbifolia extract increased the SOD, GSH PX and decreased MDA,GSH levels in serum and liver homogenate.?CONCLUSION? Sorbaria Sorbifolia extract has the effect of clearing the free radical during precarcinogenesis induced by diethylnitrosamine in rats.