实验性脑出血脑组织血流动力学变化的灌注磁共振成像研究

Dynamic study of cerebral blood flow after ICH on perfusion weighed imaging

目的 研究脑出血后脑组织血流动力学的变化规律。方法 采用立体定向自体血脑内注入法制作犬额叶脑出血模型 10只 ,分别于造模前和造模后 0 .5h、3h、6h、12h、2 4h、4 8h、72h、7d、15d进行PWI动态扫描。结果 血肿区 0 .5～72h无灌注 ,7～ 15d无或微灌注 ;血肿周边区 0 .5～ 6h低灌注 ,12h血供开始逐渐回升并接近对侧呈稍低灌注 ,部分有高灌注 ;远隔区 0 .5h～ 15d普遍稍低灌注。结论 脑出血后脑组织血流灌注普遍性降低 ,12h是血肿周边组织血流灌注变化的时间转折点。PWI是客观研究和评价脑出血后脑组织血流动力学变化的有效手段。

Objective To study the dynamic of cerebral blood flow after ICH on perfusion weighed imaging(PWI). Methods ICH models were made by injecting self-blood into forehead. 10 dogs with ICH underwent dynamic PWI before ICH and after ICH in 0.5、3、6、12、24、48、72 h and 7 d、15 d. Result In the regions of hematoma, PWI showed no-perfusion in 0.5～72 h, no or hypo-perfusion in 7～15 d; In the region of perihematoma, PWI showed hypo-perfusion in 0.5～6 h. The hypo-perfusion of perihematoma recovered and approached to the slightly hypo-perfusion of contralateral region in 12 h,even hyper-perfusion; In the contralateral regions, slightly hypo-perfusion in 0.5 h～15 d. Conclusion The state of cerebral blood flow were universality hypo-perfusion.The change key of perfusion in perihematoma were in 12 h. PWI was a effective method in studying the changes of blood flow perfusion after intracerebral hemorrhage.