胎盘异铁蛋白的表达异常与妊娠高血压综合征的关系

The relationship between PIH and abnormal expression of PLF on the human Placental Tissues

目的 通过比较正常孕妇与妊娠高血压综合征 (妊高征 )患者胎盘组织中胎盘异铁蛋白的表达 ,从分子免疫学角度探讨妊高征的病理机制。方法 用免疫组化染色法检测 30例妊高征胎盘组织 (妊高征组 )和 10例正常妊娠胎盘组织 (正常组 )中PLF的表达 ,通过高清晰度彩色病理图文分析系统对其定量分析。结果 PLF在中、重度妊高征胎盘组织中的表达明显低于轻度妊高征和正常组 ,两者间差异有非常显著意义 (P <0 .0 1)。结论 胎盘组织中PLF表达降低 ,导致母胎的免疫耐受的破坏 ,其异常的免疫反应可能是妊高征发病的重要机制。诱导PLF的产生或调节母胎的免疫耐受 ,将为临床治疗妊高征提供新的思路和方向。

Objective: To study the immunol-pathological mechanism of pregnancy induced hypertension (PIH) through the expression of placental isoferritin (PLF) of placental tissues. Methods: Immunohistochemistry was used to detect the expression of PLF in placenta tissue on 30 PIH patients (PIH group) and 10 normal pregnant women (normal group), HPIAS (High Resolution Pathological Image Analysis System)-1000 was used to determine the quantity of PLF. Results: The levels of PLF expressions on moderate and severe PIH patients were significantly lower than that of normal group and mild PIH (P<0.01). Conclusions: Abnormal expression of PLF on placental tissues, which destroy the immunologic tolerance between the mother and the fetus, may be one of the important mechanisms of the etiology of PIH. To induce the expression of PLF or to recover the immunology tolerance would be a new way of clinical treatment on PIH.