尼尔雌醇对老年高血压妇女心血管疾病危险因素的影响

The Effect of Nilestriol on Cardiovascular Disease Risk Factors in Elderly Women With Hypertension

目的 观察尼尔雌醇对老年高血压妇女心血管疾病危险因素的影响。方法 选择 41例已接受降压治疗的老年高血压妇女 ,随机分为尼尔雌醇组 (A组 )与安慰剂组 (B组 ) ,分别予以尼尔雌醇 ( 2mg ,每半月 1次 )或安慰剂 ( 2片 ,每半月 1次 )治疗共 6个月 ,采用自动生化分析法、免疫浊度法或酶联免疫吸附双抗体夹心法 (ELISA法 )分别于 0、6个月末测定患者的血糖、血脂、纤维蛋白原 (Fbg)、组织纤溶酶原激活剂 (tPA)、纤溶酶原激活剂抑制物 (PAI -1)、血管性血友病因子 (vWF)、可溶性细胞间粘附分子 (sICAM-1)及E -选择素 (E -selectin)。结果 尼尔雌醇组较安慰剂组总胆固醇 (TC)、Fbg、tPA、PAI -1、vWF、sICAM -1、E -selectin均明显降低 ,差异有统计学意义 ;甘油三酯 (TG)、低密度脂蛋白 (LDL -C)降低以及高密度脂蛋白 (HDL -C)升高 ,但差异无显著性。结论 尼尔雌醇对老年高血压妇女脂质代谢、内皮功能、纤溶凝血和炎症相关蛋白的表达具有明显改善作用 ,对血压。

Objective To observe the benefits and harms of nilestriol in elderly women with hypertension.Methods Forty-one elderly women with hypertension who had received antihypertensive therapy were randomly divided into two groups. Women in group A (n=21) received oral nilestriol, wherase those in group B(n=20) received oral placebo for six months. Blood sugar(Bs), blood lipids, soluble intercellular adhesion molecule 1(sICAM-1),E-selectin and plasma fibrinogen(Fbg),tissue-type plasminogen activator antigen(tPA),plasminogen activator inhibitor 1(PAI-1),von Willebrand factor(vWF) were measured before starting treatment and 6th month after treatment.Results Levels of total cholesterol(TC),Fbg,tPA,PAI-1,vWF,sICAM-1,E-selectin in group A were significantly lower than those in group B.Conclusions In elderly women with hypertension, nilestriol could improve the metabolism of lipids,endotheliocytes function,inflammation factors expression,thrombosis and hemostasis.