N-(2-氨基苯)-4-[N-(吡啶-3-甲氧基碳酰)氨甲基]苯甲酰胺的合成

The synthesis of N-(2-aminophenyl)-4-[N-(pyridinyl-3-me-thoxycarbonyl )-aminomethyl ] benzamide

以3-羟甲基吡啶为起始原料,采用1,1’-碳酰二咪唑(CDI)法合成中间体4-[N-(吡啶-3-甲氧基碳酰)氨甲基]苯甲 酸,然后与氯甲酸乙酯及三乙胺反应,制得活性中间体,该活性中间体不经分离直接与邻苯二胺在室温条件下反应即得 目标产物。经质谱、核磁和红外等鉴定了目标分子的结构。

The intermediate 4-[N-( pyridinyl-3-methoxy-carbonyl) aminomethyl] benzoic acid was prepared from 3-hydroxymethylpyridine by using CDI method , then it was converted to the active acid anhydride by treatment with ethyl chloroformate and triethylamine, which without further separation was treated with o-phenylenedia-mine to give the title compound.