依帕司他中间体α-甲基肉桂醛的合成

The Synthesis of α-Methylcinnamaldehyde as Intermediate of Epalrestat.

研究了由苯甲醛、丁醛合成α 甲基肉桂醛的工艺,考察了催化剂用量、原料摩尔比、反应时间对合成α 甲基肉桂醛收率的影响。其优化条件是:以乙醇作溶剂,四丁基溴化铵为催化剂,n(苯甲醛)∶n(丙醛)∶n(催化剂)1 4∶1∶0 015,室温反应6h,收率达84 6%,且过量的苯甲醛能回收。

The influence factors on the yield of α-methylcinnamaldehyde, such as kind of catalysts, dosage of catalyst, molar ratio of benzaldehyde to n propylaldehyde, and reaction time were investigated. The optimum preparation conditions are as follows∶n(benzaldehyde)∶n(n propylaldehyde)∶n(catalyst)=1.4∶1∶0.015, 6 h of reaction time with ethanol as solvent, tetrabutylammonium bromide as catalyst, and reacting at room temperature. The yield of α methylcinnamaldehyde reaches 84.6%, and surplus benzaldehyde could be used recyclely.