刺五加冻干粉针剂(ASHFI)对实验性心肌梗死犬心肌的影响

Effects of ASHFI on myocardium in dog with experimental myocardial infarction

目的 :观察刺五加冻干粉针剂 (Acanthopanaxsenticosusharmsfreeze dryinjectionASHFI)对心肌三酶、心肌梗死面积、心肌细胞超微结构的影响。方法 :采用麻醉开胸结扎犬的冠状动脉左前降支制备急性心肌梗死模型 ,取血测心肌三酶 (AST、CPK、LDH) ;组织学切片染色法和落点求积法测量心肌梗死区面积和非梗死区面积 ;采用透射电镜观察心肌细胞超微结构。结果 :刺五加冻干粉针剂可以减少心肌三酶的释放 ,降低缺血造成的心肌细胞损伤 ,减少缺血心肌的梗死范围 。

Effects of ASHFI on myocardium in dog with experimental myocardial infarction were investigated.25 dogs were divided into five groups: (1)NaCl control group,(2)ASHI control group,(3)high dose ASHFI group,(4)middle dose ASHFI group and (5) low dose ASHFI group. An acute myocardial infarction model was made by ligating left anterior descending branch in anesthetic dog.Content of myocardial enzymes(AST,CPK,LDH),infarcted area were determined and changes of myocardial ultrastructure were observed.The results showed that ASHFI can reduce myocardial impairment and diminish the infarcted coverage in ischemic myocardium.So we can draw a conclusion that ASHFI can protect cardiac muscle from injuring.