ABO血型与肿瘤易感性研究

ABO BLOOD TYPES AND TUMOURS

本文对6942例1982～1990年期间在湖北省肿瘤医院住院的肿瘤患者和69631例正常人的血型进行了比较,发现恶性肿瘤与ABO血型分布紧密相关。B血型的人对某些肿瘤的易感性明显高于其他血型。在不同部位的肿瘤中,食道癌、乳腺癌、肺癌、肝癌的患病易感性均以B血型为高,其相对危险性(RR)分别为1.33,1.24,1.22,1.57(p<0.01),而A血型的人胃癌的易感性较高,RR=1.16(p<0.05).其他4类肿瘤没有显著差异。结果提示遗传因素可能是某些肿瘤发病的一个重要因素。

The different ABO blood types and their relationship to tumors are eva- luated in cases of 6942 tumor patients compared with a group of 69631 heal- thy people as control. There are close relationship between malignant tumors and the distributing patterns ABO blood groups in population. people with type B are more susceptible to the development of cancers. Among cancers of different organs, perople with type B are associated with an elevated risk of esophageal cancer (relative risk= 1.33, p<0.05), breast cancer (RR = 1.24, p<0.01), lung cancer (RR = 1.22, p<0.05) and hepatic cancer (RR = 1.57, p<0.01) , while with a decline risk of carcinoma of nasopharynx (RR = 0.58, 0.01). The risk of gastric cancer is higher in the type A people. The ABO blood groups of other 4 categories of major cancers show no significant differences in their distributing patterns. Although the estimation of relative risk is affected by envirement factors, genetic facters may be important in the above-mentioned carcinoma.