统计参数图在Alzheimer病PET成像中的应用

Application of statistical parametric mapping in Alzheimer's disease positron emission tomography imaging

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摘要研究统计参数图(SPM)分析方法在Alzheimer病(AD)PET成像中的作用。方法:利用F-FDGPET成像方法分别对11例AD及12例对照者进行PET脑显像,采用SPM方法进行分析,总结AD的成像特点。结果:SPM分析方法显示,AD患者两侧大脑皮层顶叶、颞叶、额叶及后扣带回等部位葡萄糖代谢明显降低,左、右不对称。而两侧皮层下基底节区等结构代谢不受影响。结论:SPM方法能够客观准确显示出AD患者脑代谢降低部位,为康复治疗的脑功能研究提供一种实用的工具。 Objective:To investigate the role of statistical parametric mapping method in Alzheimer' s disease PET imaging.Method:11AD patients and12controls were studied with brain PET and the data were analyzed using SPM.The characteristics of AD PET imaging were summarized.Result:SPM results showed that cerebral metabolic rate of glucose decreased in parietal lobe,temporal lobe,frontal lobe and post cingulate bilaterally in AD patients,and right/left hemispheric asymmetry was found.The hypometablism was spared in basal ganglia and other regions.Conclusion:SPM method can show hypometablism area in AD patients objectively and accurately,which offers a practical tool in investigating brain function of rehabilitative treatment.

作者王瑞民陈英茂刘雁翎邵明哲何义杰姚树林田嘉禾

机构地区解放军总医院核医学科

出处《中国康复医学杂志》 CAS CSCD 2003年第12期728-730,共3页 Chinese Journal of Rehabilitation Medicine

关键词统计参数图 ALZHEIMER病 PET成像脑功能 SPM方法认知障碍 statistical parametric mapping Alzheimer's disease positron emission tomography

分类号 R817.4 [医药卫生—影像医学与核医学]

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统计参数图在Alzheimer病PET成像中的应用

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