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雌激素预防和治疗阿尔茨海默病的作用机制 被引量：1

Mechanisms of Estrogen in Prevention and Treatment of Alzheimer's Disease
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摘要 阿尔茨海默病简介 阿尔茨海默病(Alzheimer's disease,AD)由Alzheimer于1907年首次报道1例50余岁妇女患痴呆症而命名,即早老性痴呆症.另一类发病较迟的痴呆症,曾称为老年性痴呆症.
作者 方芳 黄敏丽
机构地区 复旦大学附属妇产科医院妇科上海
出处 《复旦学报（医学版）》 CAS CSCD 北大核心 2003年第6期623-625,共3页 Fudan University Journal of Medical Sciences
关键词 雌激素 预防 药物治疗 阿尔茨海默病 脑部血流量
分类号 R749.16 [医药卫生—神经病学与精神病学] R977.12 [医药卫生—药品]
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  • 1Manly JJ, Merchant CA, Jacobs DM, et al. Endogenous estrogen levels and Alzheimer' s disease among postmenopausal women.Neurology ,2000 Feb 22,54(4) :833
  • 2Schneider LS, Farlow MR, Henderson VW, et al. Effects of estrogen replacement therapy on response to tactine in patients with Alzheimer' s disease. Neurology, 1996,46:1580
  • 3Ohkura T, Isse K,Akazawa K, et al. Evaluation of estrogen teatment in female patients with dementia of the Alzheimer' s type.Endocrine J, 1994,41: 361
  • 4Asthana S, Craft S, Baker LD, et al. Cognitive and neuroendocrine response to transdermal eastrogen in postmenopansal women with Alzheimer' s disease: results of a placebo-controlled, double-blind,pilot study. Psychoneuroendocrinology, 1999 AUG, 24 (6): 657
  • 5Carlson LE, Sherwin BB, Chertkow HM. Relationships between mood and estradiol (E2) levels in Alzheimer's disease (AD) patien ts. J Gerontol B Psychol Sci Sco Sci,2001 Jan,55(1):47
  • 6Slooter AJ,Bronzova J,Witteman JC, et al. Estrogen use and early onset Alzheimer's disease: a population-based study. J Neurol Neurosurg Psychiatry, 1999 Dec,67(6) :779
  • 7Mulnard RA, Cotman CW, Kawas C, et al. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease:a randomized controlled trial. Alzheimer' s Disease Cooperative Study.JAMA, 2000 Feb 23,283(8): 1007
  • 8Henderson VW, Paganini HA, Miller BL, et al. Estrogen for Alzheimer' s disease in women: randomized, double-blind, placebocontrolled trial. Neurology,2000 Jan 25,54(2) :295
  • 9Sullivan JM, Vander Zwaag R, Hughes JP, et al. Estrogen replacement and coronary artery disease effect on survival in postmeopausal women. Arch Intern Med , 1990,150: 2557
  • 10Ohkwra T,Teshima Y, Isse K, et al. Estrogen increase cerebral and cerebellar blood flows in postmenopausal woman. Menopause,1994,2:13

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复旦学报（医学版）
2003年 第6期

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