卡介苗与白介素-2联合应用预防浅表性膀胱癌复发疗效观察

The clinical use of BCG and IL-2 for preventing recurrence of superficial bladder cancer.

目的 :提高浅表性膀胱癌治疗效果 ,降低膀胱癌术后复发率。方法 :对 48例浅表性膀胱癌局部手术后随机分为 2组。每组 2 4例 ,分别采用卡介苗 (BCG) +白介素 2 (IL 2 )和单用丝裂霉素 (MMC)进行膀胱灌注。结果 :48例随访12个月～ 3 6个月 (平均 2 0个月 ) ,卡介苗组有 2例肿瘤复发 ,丝裂霉素组有 8例肿瘤复发 ,二组肿瘤复发率差别有显著性意义。结论 :卡介苗 (BCG)联合IL 2预防浅表性膀胱癌术后复发疗效较好 ,副反应较少 。

Objective For preventing the recurrence of superficial transitional cell carcinoma bladder.Methods 48 patients with superficial bladder cancers were randomized in using BCG and IL-2 or MMC for preventing bladder cancers from recurring after local ablation.Results The patients have been followed up for 12～36 months (mean 20 months).Four patients had tumor recurrence in the group using BCG and IL-2 and eight in the MMC group,the difference was statistically significant (P<0.05);There were obviously more side effects in intravesical instillation with MMC than BCG and LI-2.Conclusions Intravesical instillation of BCG and LI-2 is effective in preventing superficial bladder cancer from recurring after local ablation with fewer adverse effects.The ragimen is not only reliable but also safe.