HTP方案治疗晚期非小细胞肺癌的临床观察

Therapeutic Efficacy of HTP Regimen in Patients with Advanced Non-small Cell Lung Cancer

目的 观察采用羟基喜树碱 (HPT)、鬼臼噻吩甙 (VM 2 6)和顺铂 (PDD )组成的HTP方案 ,治疗晚期非小细胞肺癌(NSCLC)的近期疗效及其不良反应。方法 3 1例晚期NSCLC患者 ,应用HTP方案 ,即HPT 6mg/m2 ,静脉滴注 ,第 1～ 5天 ;VM 2 660mg/m2 ,静脉滴注 ,第 1～ 4天 ;PDD 2 0mg/天 ,静脉滴注 ,第 1～ 5天。每 2 8天重复 ,用药 2个周期后按照WHO标准进行评价。结果 3 1例患者中CR 1例 ,PR 10例 ,NC 12例 ,PD 8例 ,总有效率为 3 5 .5 % ;主要不良反应为骨髓抑制和消化道反应。结论 HTP方案治疗NSCLC的疗效较高 ,不良反应可以耐受 。

Objective To study the efficacy and side effects of HTP regimen for advanced non-small-cell lung cancer(NSCLC).Methods 31 patients with advanced NSCLC were treated by HTP regimen(HPT 6 mg/m 2,infusion on day 1～5 plus VM-26 60 mg/m 2,infusion on day 1～4 plus PDD 20 mg/d,infusion on day 1～5,evevy 28 days).After 2 cycles,all patients were evaluated according to WHO criteria.Results One case achieved CR(3.2%),10 cases achieved PR(32.3%),12 cases NC and 8 cases PD.The total response rate was 35.5%.The major side effects were myelosuppression and troubles in gastrointenstinal tract.Conclusion It is suggested that HTP regimen is an effective and well tolerated treatment for advanced NSCLC.It deserves futher clincal observation.