子宫内膜异位症大鼠子宫内膜超微结构及丹那唑对其影响

Ultrastucture of endometrium from rat endometriosis and the effect of Danazol on its ultrastructure

目的:探讨子宫内膜异位症大鼠在位和异位子宫内膜组织超微结构的特点。方法:参照Jones方法建立大鼠子宫内膜异位症动物模型,在建模后第6周对正常对照组、模型组及丹那唑组大鼠分别取子宫内膜组织进行透射电镜观察。结果:与在位内膜相比,模型组异位内膜的基底膜不完整,线粒体有空泡,偶见坏死细胞;丹那唑治疗后,内质网扩张,空泡的线粒体和自噬体多见,细胞坏死较多。结论:子宫内膜移植到腹壁后超微结构发生了变化,丹那唑的治疗常使内膜细胞细胞器改变,细胞坏死。

Aim: To explore the ultrastructural change of eutopic and ectopic endometrium from rat uterus. Methods: According to Jones's method, rat animal model with endometriosis was established. The endometrial and endometriotic tissue was acquired for transmission election microscopic examination at six weeks after modeling. Results: In comparison with the control group , ectopic endometrium has discontinuous basement membrane and vacuolated mitochondrion; necrotic cell、 vacuolated mitochondrion、 expanded rough endoplasmic reticulum and autophagosome in ectopic endometrium were commonly seen after Danazol treatment. Conclusion: Ultrastructure of the endometrium was changed after transplantation; necrotic cell and altered organelles in ectopic endometrium are commonly seen after Danazol treatment.