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VEGF及受体与白血病研究进展

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摘要 血液系统恶性肿瘤患者多种血管生成因子含量升高 ,其含量变化与预后相关。血管内皮细胞生长因子(VEGF)是参与血管形成的主要细胞因子 ,并与内皮细胞的多种功能相关 ,VEGF含量变化与白血病临床转归有关 ,以VEGF VEGFR为靶向的治疗可促进肿瘤细胞凋亡发挥治疗作用。
作者 傅晋翔
出处 《国外医学(生理病理科学与临床分册)》 2003年第6期567-570,共4页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
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  • 1Aguayo A, Kantarjian H, Manshouri T et al. Angiogenesis in acute and chronic leukemias ant myelodysplastic syndromes[J]. Blood,2000 ;96: 2240-2245.
  • 2Hauswirth AW, Gadner H, Chott A, et al. hmmunohistochemical detection of VEGF in the bone marrow of patients with acute myeloid leukemia. Correlation between VEGF expression and the FAB category[J]. Am J Clin Pathol,2003,119:663-671.
  • 3Bruserud O,Glenjen N, Ryningen A. Effects of angiogenie regulators on in vitro proliferation and cytokine secretion by native human acute myelogenous leukemia blasts [ J ]. Eur J Haematol,2003,71:9-17.
  • 4Zachary I. Vascular endothelial growth factor[J]. Int J Bioebem Cell Biol, 1998,30:1169-1174.
  • 5Ellis LM, Takahashi Y, Liu W,et al. Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications[J]. Oncologist, 2000,5 ( suppl 1 ): 11-15.
  • 6Yancopoulos GD, Davis S, Gale NW, et al. Vascular-specific growth factors and blood vessel formation[J].Nature, 2000,407:242-248.
  • 7Giles FJ. The vascular endothelial growth factor (VEGF) signaling pathway: a therapeutic target in patients with hematologic malignancies[J].Oncologist,2001, ( suppl 5 ) :32-39.
  • 8Gille H, Kowalski J, Li B,et al. Analysis of biological effects and signaling properties of Flt-1 ( VEGFR-1 ) and KDR (VEGFR-2).A reassessment using novel receptor-specific vascular endothelial growth factor mutants [ J ]. Biol Chem, 2001,276:3222-3230.
  • 9Moehler TM,Ho AD,Goldschmidt H,et al. Angiogenesis in hematologic malignancies [J].Crit Rev Oncol Hematol,2003 ,45 :227-244.
  • 10Miquerol L, Langille BL, Nagy A. Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression[J]. Development ,2000,127: 3941-3946.

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