L-精氨酸对体外循环病人术后血浆IL-6水平的影响及意义

Effects of L-Arginine on Plasma Levels of IL-6 after Cardiopulmonary Bypass

目的 通过比较应用L 精氨酸与否对体外循环 (CPB)术后白细胞介素 6(IL 6)血浆浓度的影响 ,探讨L 精氨酸在CPB心脏手术中的抗炎作用。 方法 将 2 9例拟行心脏瓣膜置换手术的风湿性心脏病患者术前随机分成两组 :处理组 (n =15 ) ,术中给予L 精氨酸治疗 3 0 0mg/kg ;对照组 (n =14) ,未给予L 精氨酸。分别于术前、CPB停机后 2h、2 4h用酶联免疫吸附法测定两组血浆IL 6浓度。结果 ①两组病例CPB后 2h、2 4hIL 6水平与同组术前基础值比较有显著的升高 (P <0 .0 5 ) ;②CPB后 2 4hIL 6水平 ,处理组明显低于对照组 (P <0 .0 5 )。 结论 ①CPB可引起促炎症细胞因子IL 6血浆水平的显著性升高 ;②L 精氨酸可以降低CPB术后IL 6血浆水平 。

Objective To evaluate the anti-inflammatory effect of L-arginine after CPB. Methods 29 cases with rheumatic heart disease were divided into two groups randomly: treated group (group A, n=15) and control group (group B, n=14). For group A, L-arginine at 300mg/kg was given during operation;Plasma levels of IL-6 were measured by enzyme-linked immunosorbent assay technique at baseline and at 2 and 24 hours after CPB termination. Results ①There was significant (P<0.05) increase of IL-6 in both groups at 2 and 24 hours after CPB comparing with the same group at baseline before CPB; ②In group A, IL-6 level was significantly lower than in group B (P<0.05) at 24 hours after CPB. Conclusions ①CPB induced the significant increase of cytokine IL-6 after CPB. ②L-Arginine reduced plasma levels of IL-6 after CPB. L-Arginine was effective in anti-inflammation.