A study on indirect radiolabeling of IgG with carrier free ^(188)Re

A study on indirect radiolabeling of IgG with carrier free ^(188)Re

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摘要 188Re labeled monoclonal antibodies are potential candidates for use in radioimmunotherapy. S-Bz-MAG3 as a bifunctional chelating agent was used for labeling of IgG with carrier free 188Re by pre-radiolabeling of the chelating approach. The conjugation conditions were optimized. The stability of 188Re-MAG3-IgG in vitro was high. The results may be useful to the studies of 188Re labeled MAbs for radioimmunotherapy. 188Re labeled monoclonal antibodies are potential candidates for use in radioimmunotherapy. S-Bz-MAG3 as a bifunctional chelating agent was used for labeling of IgG with carrier free 188Re by pre-radiolabel-ing of the chelating approach. The conjugation conditions were optimized. The stability of 188Re-MAG3-IgG in vitro was high. The results may be useful to the studies of 188Re labeled MAbs for radioimmunotherapy.

作者 ZHANG Xiu-Li, WANG Yong-Xian, LI Jun-Ling, YIN Duan-Zhi (Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800)

出处《Nuclear Science and Techniques》 SCIE CAS CSCD 2003年第2期131-134,共4页 核技术（英文）

基金 Supported partially by Key Project of Knowledge Innovation Program of the Chinese Academy of Sciences(KJCX1-SW-08)

关键词 ^188RE 铼单克隆抗体放射免疫性疗法 Carrier free 188Re, IgG S-Bz-MAG3, Radioimmunotherapy, Bifunctional chelating agent, Indirect radiolabeling

分类号 R817 [医药卫生—影像医学与核医学]

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A study on indirect radiolabeling of IgG with carrier free ^(188)Re

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