血中同型半胱氨酸和叶酸与急性心肌梗死的相关性探讨

Study on The Relationship Between Blood Homocysteine and Folic Acid and Acute Myocardial Infarction

目的 :探讨血浆总同型半胱氨酸 (tHCY)及血清叶酸 (FA)水平与急性心肌梗死 (AMI)的相关性以及与AMI重要危险因素的相关性。方法 :应用酶联免疫法 (ELISA)测定 4 5例AMI患者和 30例对照组(Control组 )的血浆tHCY水平 ,采用12 5I标记放射免疫法测定血清FA浓度 ,应用酶法测定血脂各参数水平 ,进行比较和相关性分析。结果 :①AMI组血浆tHCY水平、高血压发生例数、血清甘油三酯 (TG)、总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL -C)水平均高于Control组 (P <0 0 5 ) ,而血清FA、高密度脂蛋白胆固醇 (HDL -C)、载脂蛋白A1(ApoA1)则低于Control组 (P <0 0 5 )。②血浆tHCY与血清FA水平呈负相关 (P <0 0 5 )。③两组中血浆tHCY与血脂各参数之间均无相关关系 (P >0 0 5 )。④年龄、吸烟、高血压对血浆tHCY的影响不显著 (P >0 0 5 )。结论 :血浆tHCY水平升高可能是引起AMI的重要危险因素。

Objective:To investigate the relationship between the levels of plasma total homocysteine (tHCY) and serum folic acid (FA) and acute myocardial infarction (AMI) and its major risk factors.Methods:45 patients with AMI and 30 controls were studied.The level of plasma tHCT was measured by enzyme linked immunosorbent assay(ELISA) serum folic acid by radioimmunoassay marked with 125 I,blood lipid by enzyme method,then compare and analyze them.Results:①The levels of plasma tHCY,serum triglyceride(TG),total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C) and the number of hypertensi in AMI group were significantly higher than those in controls (P<0 05).The levela of serum FA,high density lipoprotein cholesterol(HDL-C) and apoproteinA 1(ApoA 1) were lower than those in controls (P<0 05).②There was negtive correlation between the level of plasma tHCY and that of serum FA (P<0 05).③There was no correlation between the level of plasma tHCY and that of serum lipid.④Age,smoking and hypertension had no obvious effect on plasma tHCY in AMI patients.Conclusion:The higher level of plasma tHCY may be a major risk factor of AMI.