注射用蒺藜皂苷的抗脑缺血作用

Effect of anti-cerebral ischemia of gross saponin from tribulus terrestris

目的 :探讨注射用蒺藜皂苷 (GSTT)的抗脑缺血作用。方法 :以电阻法阻断大鼠大脑一侧中动脉造成局灶性脑缺血模型 ,观察 GSTT对脑梗死面积及行为评分的影响以探讨其抗脑缺血作用及其作用机理 ;采用大鼠血瘀模型 ,观察 GSTT对血瘀大鼠血小板聚集率及凝血时间的影响。结果 :GSTT1 0 .4、 2 0 .8和 31 .2 m g· kg- 1均可明显减少脑梗死面积 (P<0 .0 5或 P<0 .0 1 ) ;GSTT1 0 .4、 2 0 .8和 31 .2 m g· kg- 1 可明显抑制血瘀大鼠的血小板聚集率 (P<0 .0 5 ) ,还可明显延长血瘀大鼠的凝血时间 (P<0 .0 5 )。结论 :GSTT具有一定的抗脑缺血作用 。

Objective To study the effect of anti cerebral ischemia of gross saponin from tribulus terrestris (GSTT). Methods A focal cerebral ischemia model was set up through blocking one side medium cerebral artery, the effects of GSTT on infarction area and behavior scoring (neuological deficits) were observed; blood stasis model was built in rats, the effects of GSTT on platelet aggregation rate and clotting time were observed. Results GSTT with dose of 10 4, 20 8, and 31 2 mg·kg -1 could significantly decrase the infarction area and improve behavior score( P <0 05, P <0 01); GSTT with dose of 10 4, 20 8, and 31 2 mg·kg -1 could remarkably decrase the platelets aggregation rate ( P <0 05), and markedly prolong the clotting time in blood stasis rats. Conclusion GSTT has the effect of anti cerebral ischemia and its mechanism may relate to lowering platelets aggregation rate and prolonging clotting time.