胰腺癌血管生成与其生物学行为的关系研究

The Correlation between Tumor Angiogenesis and Lymph Node Metastasis in Pancreatic Carcinoma

目的 :探讨胰腺癌组织中微血管生成及其与淋巴结转移的关系。方法 :应用免疫组化S -P法以CD34单克隆抗体特异性标记胰腺癌组织血管内皮细胞及正常胰腺组织血管内皮细胞 ,检测其微血管密度 (MVD)并与临床病理特征对照分析。结果 :胰腺癌组织中微血管密度明显高于正常胰腺组织 (49.71± 2 0 .5、2 4 .3± 8.4 ,P <0 .0 1)。分化差的、或伴淋巴结转移的胰腺癌组织中的微血管密度高于分化好的、或无淋巴结转移的胰腺癌 (6 9.5 2± 14 .5 2、34.2 4± 16 .9,P <0 .0 1;6 9.73± 16 .8、34.71±15 .5 ,P <0 .0 1)。结论 :胰腺癌组织中微血管密度高于正常胰腺组织 ,其微血管生成与组织学分级。

Objective: To study the relationship between tumor micro-angiogenesis and lymph node metastasis in pancreatic carcinoma(PCA). Methods: S-P immunohistochemical method and CD34 antibody was used to detect the micro-vessel density (MVD) in pancreatic carcinoma and normal pancreatic tissue and analyse MVD with clinical pathological characters. Results: MVD in pancreatic carcinoma was 49.71±20.5, while MVD in normal pancreas tissue was 24.3±8.4. MVD in PCA of low differentiation was higher than that in PCA of high differentiation. MVD in PCA with lymph node metastasis was higher than that in PCA without lymph node metastasis. (69.52±14.52、34.24±16.9, P <0.01;69.73±16.8、34.71±15.5, P <0.01). Conclusion: MVD is higher in pancreatic carcinoma than that in normal pancreatic tissue. MVD is closely related to tissue classification and biological behavior of pancreatic carcinoma.