Graves病甲状腺组织中催乳素样物质的检测

Detection of prolactin-like substance in thyroid glands of patients with Graves'disease

目的 研究Graves病 (GD)甲状腺组织内有无催乳素 (PRL)这种重要免疫调节激素的存在及其分布。方法 应用免疫组化技术检测了 7例GD甲状腺组织和 5例对照甲状腺组织 (包括 3例结节性甲状腺肿的病变组织和 2例甲状腺腺瘤周围的正常甲状腺组织 )内有无PRL样物质存在及其分布。结果 在所研究的GD甲状腺组织标本内 ,均可于侵润的单个核细胞、其附近的血管内皮细胞和甲状腺滤泡细胞以及局部的结缔组织中检测到有PRL样物质存在。在对照组甲状腺标本内未检测到该物质存在。结论 GD甲状腺组织内有PRL样物质存在 。

Objective To study whether prolactin(PRL),an important immunomodulatory hormone,is present in thyroid glands of patients with Graves' disease(GD)and how it is distributed.Methods The presence and distribution of PRL like substance was examined by immunohistochemistry in 7 GD thyroid glands 5 control thyroid specimens(including 3 multinodular goiters and 2 samples of normal thyroid tissue adjacent to adenomas).Results PRL like substance was detectable in all GD thyroid specimens studied and mainly distributed in infiltrating mononuclear cells and vascular endothelial cells adjacent to the infiltrates.It was also present in both thyroid follicular cells nearby the infiltrates and the local connective tissue.PRL like substance was not detected in any of the control thyroid specimens studied.Conclusion PRL like substance is present in GD thyroid tissue.Its existence is associated with autoimmune phenomena.