支原体感染与低出生体重儿病因探讨

MYCOPLASMA INFECTION IN LOW BIRTH WEIGHT INFANTS

目的 探索孕妇生殖道支原体感染与低出生体重儿的病因学关系。方法 经产前检查支原体阳性孕妇 488例 ,按实验分组方法随机分成红霉素干预组和非干预组 ,比较二组间孕妇支原体感染阴转率、母婴传播率和低出生体重儿的发生率。结果 红霉素干预组解脲支原体 (Ureaplasmaurealyticum ,UU)的阴转率和母婴传播率低于非干预组 ,差异有显著性 (P <0 .0 5) ,而人型支原体 (Mycoplas mahoninis,Mh)的阴转率及母婴传播率在组间无显著性差异 (P >0 .0 5)。干预组中低出生体重儿的发生率显著低于非干预组 (P <0 .0 5)。结论 红霉素干预措施能有效地降低孕妇解脲支原体感染 ,阻断其母婴传播 ,降低低出生体重儿发生率。

Objective To investigate the relationship between urogenital mycoplasma infection and low birth weight infants. Methods 488 pregnant women with mycoplasma positive, detected by antenatal care, were randomly divided into erythromycine intervention group and nonintervention group. The mycoplasma infection negative rate, vertical transmission rate and low birth weight incidence were compared between groups. Results The Ureaplasma urealyticum negative rate and vertical transmission rate in intervention group were significantly lower than that in nonintervention group, and there were no significance in mycoplasma hominis negative rate and vertical transmission rate between groups. The low birth weight incidence in intervention group was significantly lower than that in nonintervention group(P<0.05). Conclusion Erythromycin is effective on controlling ureaplasma urealyticum infection of pregnant women, cutting off vertical transmission pathway and decreasing low birth weight incidence.