高浓度葡萄糖对兔十二指肠自律性的影响

Effects of high glucose concentrations on the auto-rhythmicity of the smooth muscle of duodenum of rabbits

目的 :观察高糖灌流对兔十二指肠平滑肌自律性的影响。方法 :取兔十二指肠段分别用正常台氏液和含糖量9.7mmol/L、1 1 .1mmol/L台氏液灌流肠管 ,记录收缩曲线。结果 :与灌流前比较 ,加入 9.7mmol/L高糖台氏液 1 0min后 ,收缩幅度抑制最明显 (P <0 .0 5 ) ,然后逐渐回升。加入 1 1 .1mmol/L的高糖台氏液 2 0min后 ,收缩幅度抑制最明显 (P <0 .0 5 ) ,然后也逐渐回升。结论

Objective:To observe the effects of high concentration of glucose on the auto rhythmicity of the smooth muscle of rabbit duodenum.Methods:Duodenum of rabbits were isolated and put into normal Tyrode solutions.Tyrode solutions coutaining high glucose(9.7 mmol/L and 11.1 mmol/L),and then the curve of contraction was recorded.Results:The contraction amplitude of the duodenum in Tyrode solution containing glucose concentrations 9.7 mmol/L was distinctly inhibited at 10 min( P <0.05),while that in Tyrode solution containing glucose of 11.1 mmol/L was distictly inhibited at 20 min( P <0.05);and then the contraction rose gradually.Conclusions:High concentration of glucose may make the contraction of duodenum inhibited.When the glucose concentrations in Tyrode solution increased,the time when the contraction of the duodenum was inhibited was prolonged.