小剂量艾司洛尔预防颈丛阻滞后心血管副反应的临床评价

Small dose of esmolol in prevention of cardiovasular side-effect after cervical plexus block

目的 :评价小剂量艾司洛尔预防颈丛阻滞后心血管副反应的临床效果。方法 :选择甲状腺手术 4 0例 ,随机分观察组2 0例 ,对照组 2 0例 ,均行“一针法”颈丛阻滞 ,监测收缩压 (SBP)、舒张压 (DBP)、心率 (HR)和血氧饱和度 (SPO2 ) ,记录麻醉前、麻醉后 3min、5min、1 0min的上述指标变化。观察组在麻醉后立即静脉注射 (静注 )小剂量艾司洛尔 (0 .5mg/kg)。 结果 :两组术前各指标差异无显著性 (P >0 .0 5 ) ,对照组麻醉前后的SBP、DBP、HR差异均有显著性 (P <0 .0 1 ) ;观察组中虽有不同程度的升高 ,但相对平稳 ,尤其HR、SBP组内比较差异均无显著性 (P >0 .0 5 ) ;两组麻醉后 ,HR和SBP 5min和 1 0min各指标差异均有显著性 (P <0 .0 0 1 )。结论

Objective:To evaluate the clinical effect of small dose of esmolol on the prevention of cardiovasular side effect after cervical plexus block.Methods:Forty patients undergoing thyroid gland operation were randomly divided into control group and esmolol group.The anaesthesia of cervical plexus block was all performed with 'single puncture'.The changes of SBP,DBP,HR and SPO 2 were inspected and recorded before anaesthesia and 3 min,5 min,10 min after anaesthesia.The patients in esmolol group were injected 0.5 mg/kg esmolol immedietly after anaesthesia.Results:The difference of each index between the two groups was not significant before operation( P >0.05).The difference of SBP,DBP and HR was marked in the control group before and during anaesthesia( P <0.01);but in the esmolol group,these indexes were relatively calm,especially those of HR,SBP( P >0.05).The difference was significant after anaesthesia between the two groups( P < 0.001 ).Conclusions:Small dose of esmolol can prevent cardiovasular side effect after cervical plexus block.