心肌缺血预适应与再灌注损伤

Myocardium Ischemic Preconditioning and Reperfusion Injury

心肌缺血预适应现象的发现使其成为心肌缺血 再灌注损伤的一种有效的治疗措施 ,近 3 0年的基础和临床研究逐步阐明了这种现象发生的机制。本文综述了该现象研究的历史和最新进展 ,以及缺血预适应对心肌细胞、内皮细胞的保护作用 ,并阐述了其与心肌梗死、心肌顿抑和心律失常的临床关系 。

The discovery of myocardium ischemic preconditionin g (IP) phenomenon makes it an effective method of reperfusion injury treatment.C linical and basic studies in nearly thirty years shed a light on the mechanism o f such phenomenon.It is reviewed in this article that the history and developmen t of these studies,the protective effect of IP on myocardium and endothelium cel ls as well as the clinical relations between IP and myocardium infarction,myocar dial stunning and arrhythmia.The newly updated anesthetic preconditioning and fa r range protection phenomenon are also mentioned in this article.