Alzheimer病成套神经心理学测验的临床研究

The Clinical Study on Neuropsychological Test in the Alzheimer Disease

目的 :探讨轻、中度阿尔茨海默病 (alzheimerdisease ,AD)认知功能损害的特点 ,为临床诊断和治疗提供参考依据。方法 :对 2 3例AD病人及 2 2例体检者进行认知功能量表的检测 ,包括简易智力状态检查 (MMSE)、日常生活能力量表 (ADL)、Pfeffer功能活动调查表 (POD )、Fuld物体记忆测验 (FOM )、快速词汇测验 (RVR)、数字广度测验 (DS)、积木测验 (BD )等。结果 :AD组病人MMSE、ADL、POD、FOM、RVR、BD、DS评分与正常对照组比较具有统计学意义 (P <0 .0 1)。AD组病人MMSE评分与ADL、POD评分呈负相关 ,MMSE评分与FOM、RVR评分呈正相关 ,MMSE与BD、DS评分无显著相关性。结论 :成套的认知功能量表检测可以为AD认知损害提供较全面的评价工具。

objective:To explore the characteristics of mild-moderate cognitive impairment of Alzheimer disease(AD)with neuropsychology.Methods:There were 23 mild-moderate AD patients and 22 normal control in the study, and neuropsychological objective were conducted in the study,including Mini Mental Status Examination(MMSE),Activities of Daily Living Scale (ADL),Pfeffer's Outpatient Disability Questionnaire (POD),Fuld Object Memory Evaluation (FOM),Rapid Verbal Retrieve (RVR),Digit Span (DS),Block Design(BD).Results:The score of MMSE、ADL、POD、FOM、RVR、BD、DS were significantly different between the patients of AD and the control subjects (P<0.01).In the AD group ,the score of MMSE was negatively correlated with ADL、POD,it was positively correlated with FOM、RVR,while it was not significantly correlated with BD、DS.Conclusion: The battery of cognitive assessment instrument was useful to evaluate the cognitive impairment of AD.